Overview

Effect of Statin Use on Aldosterone Secretion

Status:
Completed
Trial end date:
2021-03-01
Target enrollment:
Participant gender:
Summary
The purpose of this research protocol is to determine if the same effects are observed in vivo in humans through a randomized controlled study. Data regarding a novel mechanism of the widely used statin class of medications on the mineralocorticoid pathway would likely have significant clinical implications on the future management of hypertension and other cardiovascular disease given the known pleiotropy of aldosterone action.
Phase:
Phase 1
Details
Lead Sponsor:
Brigham and Women's Hospital
Treatments:
Pravastatin
Simvastatin