Effect of Statin Therapy on Disease Progression in Autosomal Dominant Polycystic Kidney Disease (ADPKD)

• Status: Completed
• Trial end date: 2012-10-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine whether the medication pravastatin will ameliorate renal and cardiovascular disease over a 3-year period in children and young adults with autosomal dominant polycystic kidney disease (ADPKD).

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Colorado, Denver
• Collaborator: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
• Treatments: Pravastatin

Criteria

Inclusion Criteria:

• Age 8-22 years

• Autosomal dominant polycystic kidney disease

• Normal kidney function

Exclusion Criteria:

• Abnormal kidney function

• Past allergic history to medications used in study

• Liver disease

• Muscle disease/dystrophy

• Pregnancy, planned pregnancy, or lactation within study period

• Inability to cooperate with or clinical contraindication for magnetic resonance imaging