Overview

Effect of Statin Preloading in STEMI in Improving PCI Outcomes

Status:
Recruiting
Trial end date:
2022-04-01
Target enrollment:
0
Participant gender:
All
Summary
To compare the effect of a single high dose of atorvastatin versus rosuvastatin preloading on microvascular coronary perfusion as determined by CTFC in patients with ST-segment elevation myocardial infarction (STEMI) undergoing PCI.
Phase:
N/A
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Beni-Suef University
Treatments:
Atorvastatin
Rosuvastatin Calcium
Criteria
Inclusion Criteria:

- The Presence of symptoms (<12h).

- ST-segment elevation of at least 0.1Mv in two contiguous leads of electrocardiogram or
new onset left bundle branch block.

- Patients age 18 to 80 years.

Exclusion Criteria:

- Previous (within 3 months) or current treatment with statins.

- Known allergy to heparin, aspirin, clopidogrel, or abciximab.

- Active severe bleeding.

- Pregnancy.

- History of major surgery or trauma.

- Significant gastrointestinal or genitourinary bleeding (<6 weeks).

- History of cerebrovascular attack (within 2 years) or cerebrovascular attack with a
significant residual neurological deficit.

- Cardiogenic shock with mechanical ventilation.