Effect of Spinal Ketorolac on Mechanical Hypersensitivity After a Total Hip Replacement
Status:
Terminated
Trial end date:
2013-06-01
Target enrollment:
Participant gender:
Summary
Chronic pain in patients following total hip replacement seems to be a significant problem.
Previous research has shown that more effective pain management in the early postoperative
period may decrease the incidence of the development of chronic pain states.
This study will evaluate whether ketorolac (a non steroidal anti-inflammatory drug) given
into the spinal fluid before surgery will reduce the area of sensitivity (or pain to light
touch) following surgery. Patients will be monitored during their postoperative hospital stay
and then contacted by telephone at 8 weeks and 6 months after surgery and questioned about
any pain they are having at their surgical site. Patients that are still experiencing pain at
6 months will be asked to return to the medical center for the study staff to assess their
pain or sensitivity at the surgical site.
Phase:
Phase 2
Details
Lead Sponsor:
James C. Eisenach, M.D. Wake Forest University
Collaborator:
National Institute of General Medical Sciences (NIGMS)