Effect of Spinal Ketorolac After Acute Opioid Exposure

• Status: Terminated
• Trial end date: 2011-01-01
• Target enrollment: 0
• Participant gender: All

Summary

This research study is being done because pain is a significant problem for patients with a variety of medical problems and following surgery or traumatic injury. Currently available pain medications may not treat all types of pain or may treat pain only at doses that produce side effects and complications. The medication in this study may have a role in better treatment of pain. The goals of this study are to see if a dose of ketorolac (non-narcotic, pain reliever), given into the fluid in the back near the spine has any effect on pain or discomfort in the skin sensation that will take place after applying capsaicin (chili pepper) cream. The sunburn-like sensation that people experience after having capsaicin cream applied is similar to, but much milder than, the pain that some people have after surgery and after certain types of nerve injuries. This study will test the effects of combining two medications that are often given together to control postoperative pain or pain from a nerve injury. The investigators are especially interested in answering two questions about the effects of ketorolac (non-narcotic pain reliever) and remifentanil (intravenous [IV] narcotic painkiller):

1. How much does remifentanil (narcotic painkiller) affect the sunburn-like painful area on your skin, which develops after applying capsaicin cream?

2. What pain relieving effects does spinal ketorolac have when given with IV remifentanil?

• Phase: Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Wake Forest School of Medicine; Wake Forest University
• Collaborator: National Institute of General Medical Sciences (NIGMS)
• Treatments: Capsaicin; Ketorolac; Ketorolac Tromethamine; Remifentanil

Criteria

Inclusion Criteria:

• healthy

• American Society of Anesthesiologist (ASA) I or II classification

• between the ages of 18-55

• weigh less than 250 pounds

• without chronic pain

Exclusion Criteria:

• taking analgesics in the last 2 weeks

• positive urine drug screen

• pregnancy

• currently taking any prescription antidepressants or other medications that are mood altering

• liver or kidney disease

• stomach ulcers

• allergies to ketorolac, lidocaine, or capsaicin cream

• lung disease (COPD)