Effect of Spinal Ketorolac After Acute Opioid Exposure
Status:
Terminated
Trial end date:
2011-01-01
Target enrollment:
Participant gender:
Summary
This research study is being done because pain is a significant problem for patients with a
variety of medical problems and following surgery or traumatic injury. Currently available
pain medications may not treat all types of pain or may treat pain only at doses that produce
side effects and complications. The medication in this study may have a role in better
treatment of pain. The goals of this study are to see if a dose of ketorolac (non-narcotic,
pain reliever), given into the fluid in the back near the spine has any effect on pain or
discomfort in the skin sensation that will take place after applying capsaicin (chili pepper)
cream. The sunburn-like sensation that people experience after having capsaicin cream applied
is similar to, but much milder than, the pain that some people have after surgery and after
certain types of nerve injuries. This study will test the effects of combining two
medications that are often given together to control postoperative pain or pain from a nerve
injury. The investigators are especially interested in answering two questions about the
effects of ketorolac (non-narcotic pain reliever) and remifentanil (intravenous [IV] narcotic
painkiller):
1. How much does remifentanil (narcotic painkiller) affect the sunburn-like painful area on
your skin, which develops after applying capsaicin cream?
2. What pain relieving effects does spinal ketorolac have when given with IV remifentanil?
Phase:
Phase 2
Details
Lead Sponsor:
Wake Forest School of Medicine Wake Forest University
Collaborator:
National Institute of General Medical Sciences (NIGMS)