Effect of Sitagliptin on Short-Term Metabolic Dysregulation of Oral Glucocorticoid Therapy

• Status: Completed
• Trial end date: 2015-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The investigators hypothesize that sitagliptin will significantly reduce impairments in insulin secretion and insulin resistance resulting from short-term oral glucocorticoid therapy.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Vermont
• Treatments: BB 1101; Dexamethasone; Dexamethasone acetate; Glucocorticoids; Sitagliptin Phosphate

Criteria

Inclusion Criteria:

• Men and women

• impaired fasting glucose

• We will stratify for weight and age.

Exclusion Criteria:

• Known Type 2 DM

• Severe disease preventing participation in study

• On chronic steroids for any reason

• Already taking DPP-4 inhibitor