Effect of Simvastatin Versus Calcium Hydroxide Intracanal Medications on Post-operative Pain and Interleukin 6 and 8

• Status: Not yet recruiting
• Trial end date: 2023-11-01
• Target enrollment: 0
• Participant gender: All

Summary

Comparing the effect of Simvastatin versus calcium hydroxide used as an intracanal medicament on Post-operative Pain and Total amount of IL-6 and IL-8 in Periapical Fluids of lower premolars in patients with Symptomatic Apical Periodontitis:

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Cairo University
• Treatments: Calcium; Simvastatin

Criteria

Inclusion Criteria:

• Patients who are free from any physical or mental handicapping condition with no underlying systemic disease.

• Lower single rooted premolars:

• Presence of pain with percussion.

• Widening in the periodontal membrane space or with small sized periapical radiolucency.

• Diagnosed clinically with symptomatic apical periodontitis.

• Patients' acceptance to participate in the trial.

• Patients who can understand pain scale and can sign the informed consent

Exclusion Criteria:

• Medically compromised patients

• Pregnant women

• Patients who are allergic to non-steroidal anti-inflammatory drugs.

• Patients with two or more adjacent teeth requiring root canal therapy

• If analgesics or antibiotics have been administrated by the patient during the past 24 hours preoperatively.

• Patients reporting bruxism or clenching.

• Teeth associated with acute periapical abscess, swelling or a fistulous tract.

• Greater than grade I mobility or pocket depth greater than 5mm.

• Non restorable teeth.

• Immature teeth.

• Teeth with previous endodontic treatment.

• Radiographic evidence of external or internal root resorption vertical root fracture, perforation, calcification.