Effect of Sildenafil in Individuals With Migraine Pretreated With Erenumab
Status:
Recruiting
Trial end date:
2024-02-01
Target enrollment:
Participant gender:
Summary
An outstanding scientific question, that merits further investigation, is whether dilation of
intracranial arteries is implicated in the pathogenesis of cephalic pain in migraine. Here,
we hypothesize that experimentally-induced dilation of intracranial arteries using intake of
sildenafil (a potent vasodilator) can induce cephalic pain with migraine-like features in
people with migraine, who prior to the infusion are administered erenumab (anti-calcitonin
gene-related peptide (CGRP) receptor monoclonal antibody.