Effect of Sildenafil Citrate on Mid Luteal Phase Uterine Artery Blood Flow in Patients With Recurrent Pregnancy Loss

• Status: Completed
• Trial end date: 2019-07-01
• Target enrollment: 0
• Participant gender: Female

Summary

Patients with recurrent pregnancy loss are known to have decreased uterine artery blood flow. Nitric oxide plays a major role in increasing uterine blood flow during the luteal phase. This study is done to evaluate the effects of sildenafil on blood flow indices in the patients with recurrent pregnancy loss due to impaired uterine artery blood flow.

• Phase: Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Ain Shams University
• Treatments: Sildenafil Citrate

Criteria

Inclusion Criteria:

1. History of 2 or more unexplained recurrent miscarriage.

2. Child bearing period (18-35 years old).

3. Non pregnant state.

4. Regular menstrual cycles for the previous three months before the study.

5. No hormonal contraception or intrauterine device.

6. impaired uterine artery blood flow (PI >2.02) (Mansour et al., 2018).

Exclusion Criteria:

• 1-Having any possible causes of abortion: anatomical, genetic, endocrinological, infectious, or immunological.

2- Autoimmune disorders which may affect blood vessels and their blood flow (systemic lupus).

3- Systemic disease that might affect the hemodynamic indices (e.g. thrombocytopenia, thyrotoxicosis … etc.).

4- Diagnosed or treated thrombophilia. 5- Any vascular disease (e.g. coronary artery disease). 6- History of oophorectomy. 7- History of consanguinity. 8- Family history of chromosomal abnormalities (e.g. trisomy 21, trisomy 13… etc.).