Effect of Serotonin and Levodopa in Ischemic Stroke

• Status: Completed
• Trial end date: 2019-10-31
• Target enrollment: 0
• Participant gender: All

Summary

Cortical plasticity plays a pivotal role in functional recovery after a stroke. Neurotransmitter release, facilitates the creation of new synapses and promotes brain plasticity. In a pilot study, will evaluate the potential benefit of drugs that increase the release of neurotransmitters in patients with first stroke.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Hospital de Granollers
• Treatments: Carbidopa; Carbidopa, levodopa drug combination; Citalopram; Dexetimide; Levodopa; Serotonin

Criteria

Inclusion Criteria:

• • Patients with a first stroke with NIHSS 5-20 points

• Patients without aphasia to avoid interference in the assessment of depression and cognitive impairment

• Patients with independent functional status prior to stroke (mRS <3)

• Patients without prior cognitive impairment or depressive syndrome assessed by medical history with the patient and family.

• The assigned treatment initiated within the first five days of stroke

Exclusion Criteria:

• • Patients with prior myocardial or cerebral hemorrhage

• Patients with TIA

• Patients with aphasia

• History of cognitive impairment or prior depressive syndrome

• Patients with no independent functional status mRS greater than or equal to 3

• Underlying disease hopefully less than one year of life.

• Patient pre-treatment with levodopa, an antidepressant or neuroleptic.