Effect of Selective Serotonin Reuptake Inhibitors (SSRIs) and an Opioid on Ventilation
Status:
Not yet recruiting
Trial end date:
2024-12-01
Target enrollment:
Participant gender:
Summary
This study is designed to evaluate the effects of the coadministration of paroxetine or
escitalopram with an opioid on ventilation. Ventilation will be assessed using a rebreathing
methodology. This study will evaluate chronic and acute dosing of paroxetine and escitalopram
combined with an opioid as well as chronic and acute dosing of the two drugs without
coadministration of an opioid.
This study is a 3-period, randomized, placebo-controlled crossover study conducted with 25
healthy participants. Each participant will receive each of the 3 treatments
(placebo/oxycodone, paroxetine/oxycodone, escitalopram/oxycodone) in a randomized order.