Effect of Selective Laser Trabeculoplasty Versus Travoprost on Circardian Intraocular Pressure

• Status: Completed
• Trial end date: 2016-02-01
• Target enrollment: 0
• Participant gender: All

Summary

The investigators conduct this study to access the effect of selective laser trabeculoplasty on 24-hour circadian tension curves of patients with open-angle glaucoma, normal tension glaucoma and ocular hypertension. This treatment effect is compared with that of the prostaglandin analogue, travoprost.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Prince of Songkla University
• Treatments: Benzalkonium Compounds; Travoprost

Criteria

Inclusion Criteria:

• Age > 18 year-old

• Patients who were diagnosed as primary open-angle glaucoma, normal tension glaucoma, and ocular hypertension either newly diagnosed or currently on medical therapy.

• Agree to participate in the study, accept to be randomized to receive treatment, and willing to sign an informed consent

Exclusion Criteria:

Related to the severity of disease and visual acuity status

• Advance glaucoma in the study eye

• Have a very high intraocular pressure that need immediate treatment to prevent retinal vein occlusion (intraocular pressure >30 mmHg)

• Currently on maximal tolerated medical treatment and unable to control intraocular pressure

• Currently on oral carbonic anhydrase inhibitor for intraocular pressure control

• Single eye, the other eye blind from any cause

Related to surgical procedures

• Prior laser trabeculoplasty

• Prior glaucoma surgery

• Prior retinal surgery

• Underwent less than 3-month cataract extraction

• Potential need for other ocular surgery within the 2-3-month follow-up period since enrollment Related to underlying and ocular history

• History of diabetic retinopathy staged as severe non-proliferative or worse

• Narrow iridocorneal angle

• Ocular condition precluding visualization of trabecular meshwork

• Recently have ocular inflammation of any cause

• Previous history of ocular trauma

• Pregnant or breast-feeding women Related to the difficulty of having reliable measurements

• History of refractive surgery or any keratoplastic procedure

• Corneal opacities or diseases making no suitable tonometry

• Subjects with having poor or eccentric fixation or nystagmus

• Excessive eye squeezing

• Unable to lay down for measuring intraocular pressure in supine position during the night time

• Unable to have intraocular pressure checked every 2-hour such as have complicated underlying diseases or having sleep deprivation Related to allergy

• Known allergy to topical anesthesia

• Known allergy to fluorescein solution

• Known allergy to travoprost Related to compliance

• Impairment preventing adequate understanding to sign an informed consent

• Subject has demonstrated potential for non-compliance with the study protocol

• Unwilling to be randomized to receive treatment

• Unwilling to be washed out from currently treated drug(s).