Effect of Salsalate on Bed Rest-Induced Vascular Dysfunction
Status:
Completed
Trial end date:
2014-12-01
Target enrollment:
Participant gender:
Summary
Physical inactivity induces vascular dysfunction and glucose intolerance during five days of
bed rest. This study will investigate the effects of salsalate on these responses. Subjects
will be randomized to treatment with salsalate or placebo for four days prior to initiation
of bed rest. Vascular function in the brachial artery will be determined by ultrasound prior
to treatment and before and after the 5-day bed rest protocol. We hypothesize that treatment
with salsalate will be associated with protection again the development of glucose
intolerance and vascular dysfunction in this setting.