Overview
Effect of Salmeterol on Brain-Derived Neurotrophic Factor (BDNF) Concentrations in Asthma
Status:
Completed
Completed
Trial end date:
2007-04-01
2007-04-01
Target enrollment:
0
0
Participant gender:
All
All
Summary
BDNF has been linked to the pathogenesis of airway hyperresponsiveness in asthma. In this trial, the impact of a treatment with salmeterol and salmeterol / fluticasone on BDNF concentrations will be assessed in patients with asthma. The investigators hypothesize that salmeterol impacts on BDNF concentrations in patients with asthma.Phase:
N/AAccepts Healthy Volunteers?
NoDetails
Lead Sponsor:
University of RostockCollaborator:
GlaxoSmithKlineTreatments:
Fluticasone
Salmeterol Xinafoate
Criteria
Inclusion Criteria:- Age > 18 years, a physician's diagnosis of allergic asthma
- A documented sensitization to aero-allergens (pollen, animal hair, or house dust mite)
- A pre-bronchodilator forced expiratory volume in the first second (FEV1) > 80 % of the
predicted value (% predicted), a provocative concentration of histamine causing a 20 %
fall in FEV1 (PC20) of < 8 mg histamine / ml
Exclusion Criteria:
- No regular treatment (only short-acting inhalers on demand were allowed)
- No history of or evidence for any other chronic disease than asthma
- No history of smoking, absence of any signs or symptoms of an infection