Effect of Salicylate on Glucose Metabolism in Insulin Resistance States
Status:
Completed
Trial end date:
2008-05-01
Target enrollment:
Participant gender:
Summary
Data supports diet induced obesity leads to activation of the IKK/NF-kB inflamatory pathway
and that chronic inflammation leads to insulin resistance and diabetes. In rodents,
salicylates inhibit IKK/NF-kB and may improve insulin sensitivity. We will study if this is
true in people.
Phase:
Phase 1/Phase 2
Details
Lead Sponsor:
Joslin Diabetes Center
Collaborators:
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) National Institutes of Health (NIH)