Overview

Effect of S-ketamine Anesthetic on Inflammatory Response in Septic Patients Undergoing Abdominal Surgery

Status:
Recruiting
Trial end date:
2023-10-30
Target enrollment:
0
Participant gender:
All
Summary
This study is a randomized, double-blinded, controlled design. In this study, low doses of S-ketamine were selected for surgury treatment in septic patients under general anesthesia , Meanwhile, activity of HO-1 protein , oxidative stress and inflammatory markers in serum are measured to evaluating the effects of S-ketamine Anesthetic on inflammatory response in septic patients undergoing abdominal surgury. In addition,It is very necessary to make use of the advantages of low-dose S-ketamine in anti-inflammation, and avoid the side effects of mental symptoms, so as to guide the new direction of perioperative clinical application of S-ketamine.
Phase:
N/A
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Tianjin Nankai Hospital
Treatments:
Esketamine
Ketamine
Criteria
Inclusion Criteria:

- Patients with sepsis requiring surgical treatment under general anesthesia should be
transferred to ICU with endotracheal intubation for further treatment after surgery

- 18≤ age ≤85, gender and nationality is not limited

- Agree to participate in this study and sign the informed consent

Exclusion Criteria:

- Declined to participate in this study

- Patients in pregnancy or with drug allergy in this study

- Patient had chronic or acute respiratory ailments

- long-term preoperative continuous ventilatory support or oxygen dependency

- Patients are now being included in another study

- In the opinion of the attending physician or researcher, there are other conditions
that are not appropriate for the study