Effect of Rosuvastatin on Amnesia and Orientation Through Galveston Outcome Amnesia Test in Moderate Head Injury

• Status: Completed
• Trial end date: 2007-10-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine whether rosuvastatin is effective in the management of moderate head injury by improving amnesia and orientation.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Universidad Autonoma de San Luis Potosí
• Collaborators: AstraZeneca; Hospital Central "Dr. Ignacio Morones Prieto"
• Treatments: Rosuvastatin Calcium

Criteria

Inclusion Criteria:

• Man or woman >16 and <50 years with HI less 24 hours in progression and Glasgow between 9 y 12.

• Man or woman >16 and <50 years with HI and Glasgow l3, with lesions in TC scan.

• Acceptance of family to participate (first grade).

Exclusion Criteria:

• History of HI with disability

• History of neurological or psychiatric disease with disability.

• Administration 24 hrs previous of: fibrates, niacin, ciclosporin, azoles, macrolides, inhibitors of protease, nefazodone, verapamil, diltiazem,amiodarone.

• Existence of systemic injury with life in compromise (massive bleeding, exposition of bone in fracture, hepatic or splenic laceration or in great vessels and shock).

• Administration of THAM, mannitol, barbiturates, corticosteroids, scavengers of free radicals, inhibitors of lipidic peroxidation, indometacin, calcium antagonist, antagonists of neurotransmitters

• Existence of intracranial lesion which needs surgery.

• Lesions not classifiable or in brainstem.

• Allergy to the drug.

• Hepatopathy or myopathy (or) history of this, or clinical data of hepatic disease.

• Management previous in other Hospital.

• Pregnancy