Overview

Effect of Rosuvastatin in Abdominal Sepsis

Status:
Unknown status
Trial end date:
2011-09-01
Target enrollment:
0
Participant gender:
All
Summary
The purpose of this study is to determine whether rosuvastatin is effective as a coadjuvant drug in the integral management of abdominal sepsis acknowledged by surgery.
Phase:
Phase 2
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Universidad Autonoma de San Luis Potosí
Treatments:
Rosuvastatin Calcium
Criteria
Inclusion Criteria:

1. Man or women > 18 and < 80 years old with abdominal sepsis, confirmed diagnosis by
surgery of broad peritonitis before 48 hours in progression

2. Injury by steel or firearm with contaminated abdominal cavity

3. APACHE II major or equal than 8

4. Acceptance to be included

Exclusion Criteria:

1. Ingestion of: fibrates, niacin, cyclosporin, azoles, macrolides, inhibitors of
protease, nefazodone, verapamil, diltiazem, amiodarone

2. Hypovolemic shock III and IV after get surgery

3. Cardio-respiratory failure pre or trans surgery

4. Allergy to used drug

5. Use previous of statin

6. Hepatopathy or myopathy and(or) history, hepatic failure (Child B y C)

7. Management in other Hospital

8. Pregnancy

9. Thoracic injury, head injury (moderate and severe), multiple fractures or with bone
exposition, rectal injury