Effect of Resveratrol on Age-related Insulin Resistance and Inflammation in Humans
Status:
Completed
Trial end date:
2015-03-01
Target enrollment:
Participant gender:
Summary
Human aging is associated with increased fat mass, insulin resistance and systemic
inflammation. In addition to overall increases in fat mass, accumulation of lipid in such
insulin-sensitive tissues as liver and skeletal muscle appears to contribute importantly to
insulin resistance. Furthermore, age-related decreases in muscle mitochondrial ATP production
rate and mitochondrial DNA copy number are likely to contribute to impaired insulin-mediated
glucose disposal, as well as decreased muscular endurance and activity levels. Additionally,
systemic inflammation is now believed to contribute to insulin resistance and thus ultimately
to many age-related disorders, including diabetes mellitus, Alzheimer's disease,
atherosclerosis and many cancers.
Phase:
Phase 2
Details
Lead Sponsor:
Albert Einstein College of Medicine Albert Einstein College of Medicine of Yeshiva University