Effect of Resin, Calcium Silicate and Silicone Based Root Canal Sealers on Postoperative Pain
Status:
Not yet recruiting
Trial end date:
2021-12-01
Target enrollment:
Participant gender:
Summary
After endodontic procedures, depending on the individual and many variables, postoperative
pain can be occur within hours and continue for days following the treatment. It is thought
that acute inflammation that develops due to chemical, mechanical or microbial injuries in
the periapical tissue after endodontic treatment causes postoperative pain. Materials used
for root canal obturation can reach periodontal tissues through the apical foramen, lateral
canals or leakage and may affect the healing process in the periodontium. For this reason,
knowing the properties of root canal obturation materials is important in terms of preventing
postoperative pain.
Calcium silicate-based root canal sealer are recommended to be used as they enhance healing
after endodontic treatment by promoting differentiation of odontoblasts and the release of
bioactive compounds. At the same time, it has been reported that it has less cytotoxic effect
compared to the resin-based AH Plus, which is widely used for root canal). Silicone-based
root canal sealers have good biological properties on human ligament periodontal fibroblasts.
It has been reported that GuttaFlow Bioseal root canal sealer, which has been used in recent
years, has less cytotoxic effect than GuttaFlow2, MTA Fillapex and AH Plus sealers. Ateş et
al.(2019) evaluated that the effects of different root canal sealers on postoperative pain
and reported that the use of iRoot SP or AH Plus did not significantly affect pain levels,
but iRoot SP sealer required less analgesic intake than AH Plus sealer. Aslan et al. (2020)
concluded in their study that calcium silicate and resin-based root canal sealers are similar
in terms of postoperative pain and need for analgesic intake. Ferreira et al.(2020) compared
the effects of AH Plus, Endofill and MTA Fillapex root canal sealers on postoperative pain
and stated that all three root canal sealers cause similar pain levels.
When reviewing the studies on postoperative pain, it is seen that mostly resin and calcium
silicate based root canal sealers are evaluated. Studies on calcium silicate and
silicone-based root canal sealers seem to focus more on cytotoxicity. However, no study has
been found in the literature on the effect of GuttaFlow Bioseal sealer on postoperative pain,
which has been popularity in recent years and has low cytotoxicity. Acoording to this
information, it is planned to conduct the research described below, on the effect of calcium
silicate-based (iRoot SP), silicone-based (GuttaFlow Bioseal) and rezin-based (AH Plus)
sealer on postoperative pain.