Overview

Effect of Remifentanil Boluses on Hemodynamics in Skull Pin Insertion

Status:
Completed
Trial end date:
2010-01-01
Target enrollment:
0
Participant gender:
All
Summary
Skull pin insertion during craniotomies is a brief, intensely stimulating, painful stimuli occurring during the conduct of a neurosurgical or spine anesthetic. Remifentanil is an ultra short acting opioid that has been successfully used to blunt hemodynamic responses in a wide variety of clinical scenarios. It is our intention to ascertain the optimal dose for blunting the hemodynamic response to skull pin insertion using remifentanil.
Phase:
N/A
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
University Health Network, Toronto
Treatments:
Remifentanil
Criteria
Inclusion Criteria:

Patients requiring skull pin fixation and general anesthesia for:

- Elective cervical spine surgery

- Elective craniotomies/brain tumor resection

- Elective transsphenoidal pituitary hypophysectomies

Exclusion Criteria:

Patients with evidence of raised intracranial pressure:

- GSC < 15

- Radiological evidence of significant rise in ICP (e.g. midline shift)

- Vascular anomalies in the brain