Effect of Regulated Add -on Sodium Chloride Intake on Stabilization of Serum Lithium Concentration in Bipolar Disorder
Status:
Recruiting
Trial end date:
2022-12-31
Target enrollment:
Participant gender:
Summary
Bipolar affective disorder or manic -depressive psychosis (MDP) is a mood disorder affecting
2.4% of the global population . Lithium is considered as the "gold standard" for the
treatment of bipolar disorder but the clinical use of lithium is often restricted due to its
narrow therapeutic range and adverse effects.
In a published case report, Bleiwiss H found that sodium chloride supplementation diminished
the adverse effects caused by lithium The literature search also revealed that till date,
there is no published clinical study evaluating the effect of dietary intake of sodium in
preventing the fluctuations of serum lithium level and lithium toxicity Therefore, a
randomized clinical trial has been designed to evaluate the effect of regulated add -on
dietary sodium chloride on serum lithium levels in bipolar disorder.
Phase:
Phase 4
Details
Lead Sponsor:
All India Institute of Medical Sciences, Bhubaneswar