Effect of Reduction of Inflammatory Status on Glucose Metabolism in Overweight Men

• Status: Completed
• Trial end date: 2005-07-01
• Target enrollment: 0
• Participant gender: Male

Summary

Overweight increases the risk to develop chronic diseases including type-2 diabetes and cardiovascular disease. The low-grade inflammatory status often seen in overweight subjects is thought to play an important role in disease development.

The purpose of this study is to determine the role of inflammation on glucose metabolism and insulin resistance. In this study the effect of the anti-inflammatory treatment diclofenac on markers of inflammation and on parameters of glucose metabolism will be studied.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: TNO
• Treatments: Diclofenac

Criteria

Inclusion Criteria:

• Body Mass Index (BMI): 25.1 - 32.0 kg/m2

• Normal Dutch eating habits

Exclusion Criteria:

• diabetes, cardiovascular disease or hypertension

• Not suitable to receive diclofenac treatment

• Smoking

• Extreme physical activity (more than 6 hours/week)

• Reported slimming or medically prescribed diet