Effect of Ranolazine on Myocardial Perfusion Assessed by Serial Quantitative Exercise SPECT Imaging
Status:
Completed
Trial end date:
2012-09-01
Target enrollment:
Participant gender:
Summary
This study enrolled participants with documented exercise-induced myocardial ischemia in
order to evaluate whether ranolazine, when taken prior to exercise, can improve blood flow to
the heart (myocardial perfusion), as assessed by exercise-induced myocardial perfusion defect
size (PDS) and total perfusion deficit (TPD), using gated single photon emission computed
tomography (SPECT) myocardial perfusion imaging (MPI).
This was a 2-period crossover study. The last dose of each period must have been taken 3-4
hours prior to conduct of the exercise SPECT MPI. After the research exercise SPECT MPI was
performed at the end of Period 1, participants discontinued the treatment they were
randomized to for that period and began the other treatment in Period 2.