Effect of Ramosetron in Prevention of Intrathecal Morphine Induced Nausea and Vomiting

• Status: Completed
• Trial end date: 2015-03-01
• Target enrollment: 0
• Participant gender: All

Summary

We would like to know the prophylactic anti-emetic effect of ramosetron compare to ondansetron in patient undergone total knee arthroplasty with spinal anesthesia and intrathecal morphine .

• Phase: Phase 3
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Thammasat University
• Treatments: Anesthetics; Morphine; Ondansetron; Ramosetron

Criteria

Inclusion Criteria:

• Patients aged 50-80 years with a diagnosis of primary OA undergoing unilateral TKA

• American Society of Anesthesiologist (ASA) physical status I-III

• Giving written informed consent

Exclusion Criteria:

• Body mass index (BMI) > 35 kg/m2

• Unable to undergo spinal anesthesia

• History of allergic to study drugs

• Impaired renal and/or hepatic function

• Use of systemic steroids and anti-emetics within 24 hours of operation