Effect of Quinine Hydrochloride in Overweight Population on Food Intake, Hunger and Gut Peptide Release
Status:
Recruiting
Trial end date:
2022-10-29
Target enrollment:
Participant gender:
Summary
The worldwide increase in the prevalence of obesity is a cause of great concern.
Pharmacological treatment options are being explored at the moment with a major focus on the
hormones produced by the gastrointestinal tract which regulate hunger and satiation/satiety.
Modulating the release of these hormones via bitter substances reduced appetite-related
sensations and gastrointestinal motility in lean female volunteers.
Intragastric administration of a quinine-solution has shown to decrease hunger sensations in
healthy female volunteers. Now, we want to examine whether this effect is still seen in an
overweight female population.