Effect of Quetiapine on Sleep Architecture in Bipolar Depression and Major Depressive Disorder
Status:
Completed
Trial end date:
2009-01-01
Target enrollment:
Participant gender:
Summary
Clinical practice indicates that Quetiapine has sedating properties, and its sedative effects
may play an important role in restoring quality of sleep in patients with various psychiatric
conditions who frequently experience sleep disturbances as part of their illness. It is well
known that depressive disorders are very frequently associated with significant sleep
disturbance. Sleep disruption is a feature of Bipolar Disorder during both Depressed and
Manic/Hypomanic episodes. Considering that Seroquel has good antidepressant properties
(Calabrese, 2004), the investigators suggest that Seroquel's effect on sleep architecture
contributes to its antidepressant properties.