Effect of Quercetin on Green Tea Polyphenol Uptake in Prostate Tissue From Patients With Prostate Cancer Undergoing Surgery

• Status: Completed
• Trial end date: 2021-06-10
• Target enrollment: 0
• Participant gender: Male

Summary

This randomized pilot phase I trial will evaluate if quercetin enhances the uptake of green tea polyphenols in the prostate tissue of men taking green tea extract and undergoing radical prostatectomy. Side effects of green tea extract and quercetin in combination with green tea extract will also be evaluated. In preclinical studies, green tea polyphenols have anticancer and cancer preventative effects in a number of malignancies. Likewise, in preclinical studies quercetin was found to enhance the anticancer effects of green tea. This trial is designed to translate these findings forward in a short-term human intervention trial.

• Phase: Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Jonsson Comprehensive Cancer Center
• Collaborator: National Cancer Institute (NCI)
• Treatments: Quercetin

Criteria

Inclusion Criteria:

• Subjects consent to participate in the trial

• The subject has a diagnosis of adenocarcinoma of the prostate

• The subject is scheduled to undergo radical prostatectomy

• The subject agrees to stop consuming tea or tea-containing products and quercetin supplements throughout the entire intervention period except for the green tea extract and quercetin provided during study intervention

Exclusion Criteria:

• History of hepatitis or liver dysfunction

• Ongoing alcohol abuse

• Significant medical or psychiatric conditions that would make the patient a poor protocol candidate

• Prior sensitivity or allergic reaction to tea, tea products or tea and quercetin supplements

• Allergies to multiple food items or nutritional supplements

• Taking luteinizing hormone-releasing hormone (LHRH) agonists, androgen receptor blocking agents, finasteride, or has undergone bilateral orchiectomy