Effect of Propofol on Remifentanil-induced Postoperative Hyperalgesia in Patients Undergoing Thyroid Surgery

• Status: Unknown status
• Trial end date: 2011-07-01
• Target enrollment: 0
• Participant gender: All

Summary

The investigators hypothesize that propofol infusion during surgery can affect the remifentanil hyperalgesia compared to sevoflurane inhalation.The outcome will be measured by a verbal numerical rating score (VNRS) and mechanical punctuating pain by electronic von frey filament.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Gangnam Severance Hospital
• Treatments: Propofol; Remifentanil; Sevoflurane

Criteria

Inclusion Criteria:

• Patients undergoing thyroidectomy

• Age 20-65

• American Society of Anesthesiologists physical status classification I or II

Exclusion Criteria:

• History of chronic pain, Regular use of analgesic, antiepileptic or antidepressive drugs

• History of drug & alcohol abuse

• Psychiatric disorder

• Use of opioids within 24hrs

• Renal disease with decreased glomerular filtrate ratio

• Neuromuscular disease, Severe cardiac disease