Effect of Propofol on Postoperative Sleep Quality in Elderly Patients With Sleep Disorders

• Status: Not yet recruiting
• Trial end date: 2023-12-25
• Target enrollment: 0
• Participant gender: All

Summary

This study intends to conduct postoperative sleep intervention for elderly patients with sleep disorders undergoing surgery. We hope to explore whether propofol can improve the postoperative sleep quality of elderly patients with sleep disorders, prevent the occurrence of postoperative delirium in elderly patients, relieve patients' pain, promote patients' postoperative rehabilitation, and provide reference for realizing the rapid rehabilitation of elderly patients with sleep disorders through intravenous administration of research drugs, on the premise of improving patient comfort and ensuring patient safety.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Xiangya Hospital of Central South University
• Treatments: Dexmedetomidine; Propofol

Criteria

Inclusion Criteria:

• age ≥ 60 years old

• Chronic insomnia

• Pittsburgh Sleep Quality Index>5 points

• Daytime functional impairment (component Ⅶ ≥2 points in PSQI)

• Patients undergoing elective surgery

• Patients to be admitted to ICU after surgery

• Voluntarily participate in the study and sign the informed consent

Exclusion Criteria:

• Subjects with severe hemodynamic instability

• Subjects with difficult airway

• Patients with other sleep disorders (including sleep apnea syndrome, exercise-related sleep disorders and other types of sleep disorders)

• Subjects requiring sedation, mechanical ventilation, or sleep prior to medication;

• Severe liver dysfunction (Child-Pugh GRADE C)

• Severe renal dysfunction (requiring dialysis before surgery)

• Patients with allergies to study drugs and related ingredients

• Patients with severe dementia, low cognitive function, language impairment, severe hearing or vision impairment, mental disorder, coma and other conditions cannot complete the assessment