Effect of Propofol on Cardioprotective Role of Remote Ischemic Preconditioning (RIPC)

• Status: Completed
• Trial end date: 2018-02-07
• Target enrollment: 0
• Participant gender: All

Summary

This study involves research using human subjects (cardiac surgical patients) to evaluate the effect of remote ischemic preconditioning (RIPC) on cardioprotective outcomes. RIPC applied to upper or lower extremities has been shown cardioprotective role by lowering release of cardiac troponin in patients with cardiac diseases. However, it is not clear whether anesthetics, such as propofol or sevoflurane, may impair the cardioprotective effect of RIPC in cardiac surgical patients. Therefore, the purpose of the study is to compare the effects of anesthetics on cardioprotection of RIPC in patients undergoing cardiac surgery.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Seoul National University Hospital
• Treatments: Anesthetics; Propofol; Sevoflurane

Criteria

Inclusion Criteria:

• ASA class I~III patients undergoing cardiac surgery using cardiopulmonary bypass

Exclusion Criteria:

• Cardiac surgery without using cardiopulmonary bypass

• Descending thoracic aortic surgery

• Strenuous exercise, excessive alcohol or caffeine intake 24 hours before remote ischemic preconditioning

• Left ventricular ejection fraction < 30%

• Uncontrolled hypertension or diabetes mellitus

• Severe renal or hepatic dysfunction

• Patients on hemodialysis

• Patients with arterio-venous fistula on arms or any reason to protect arms

• Peripheral vascular or nerve disease, bleeding tendency

• Preoperative use of IABP, ECMO, or ventricular assist devices

• Emergency operation, redo operation

• Refuse to enroll

• Pregnancy

• Preoperative use of beta-blockers