Effect of Propofol-Dexmedetomidine on Cerebral Oxygenation and Metabolism During Brain Tumor Resection
Status:
Completed
Trial end date:
2017-11-01
Target enrollment:
Participant gender:
Summary
Despite theoretical benefits of intravenous agents, volatile agents remain popular. In a
study comparing desflurane, isoflurane, and sevoflurane in a porcine model of intracranial
hypertension, at equipotent doses and normocapnia, cerebral blood flow (CBF) and
intra-cranial pressure (ICP) were least with sevoflurane.
Propofol is the most commonly used intravenous anesthetic. It has many theoretical advantages
by reducing cerebral blood volume (CBV) and ICP and preserving both autoregulation and
vascular reactivity. Neurosurgical patients anaesthetized with propofol were found to have
lower ICP and higher CPP than those anaesthetized with isoflurane or sevoflurane.
The well known pharmacodynamic advantages of intravenous anesthetics may give this group of
drugs superior cerebral effects when compared with inhalation anesthetics.