Overview

Effect of Prolonged Sedation With Dexmedetomidine on Long-term Prognosis of Patients With Acute Ischemic Stroke After Mechanical Thrombectomy

Status:
Recruiting
Trial end date:
2023-12-31
Target enrollment:
0
Participant gender:
All
Summary
Dexmedetomidine can attenuate the activity of sympathetic nervous system under stress response and improve ischemia-reperfusion injury. The investigators hypothesized that the prolonged sedation of dexmedetomidine after thrombectomy may improve the clinical outcome of acute ischemic stroke patients.
Phase:
Phase 4
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Beijing Chao Yang Hospital
Treatments:
Dexmedetomidine
Criteria
Inclusion Criteria:

- NIHSS≤25

- mRS score before stroke was less than 3

- Acute ischemic stroke (including anterior circulation)

- mTICI rate 2b or 3

- According to the 2018 AHA/ASA guidelines for the management of acute ischemic stroke,
patients who plan to receive mechanical thrombectomy under local anesthesia and
sedation

- Informed consent was signed by patient or legal representative

Exclusion Criteria:

- Intracerebral hemorrhage occurred in the responsible vessel area in the past 6 weeks

- Patients who had received stent treatment at the responsible vessel in the past

- Neurological function was restored at or before angiography

- Patients who are allergic to heparin, aspirin, clopidogrel, rapamycin, lactic acid
polymer, poly (n-butyl methacrylate), stainless steel, anesthetics and contrast agents
or have contraindications

- Hemoglobin was less than 70g/L, platelet count was less than 50×109/L, international
normalized ratio (INR) greater than 1.5 (irreversible), there are uncorrectable
bleeding factors

- Blood glucose < 2.7 mmol/L or > 22.2 mmol/L

- Severe liver or kidney disfunction, ALT>3 times the upper limit of normal value or
AST>3 times the upper limit of normal value, creatinine>1.5 times the upper limit of
normal value

- Pregnant or lactating women

- Previous history of mental illness

- Stroke with other acute diseases or postoperative stroke of other operation

- Heart rate less than 50bpm, second or third degree of atrioventricular block (except
for pacemaker implantation), systolic blood pressure less than 90mmHg (two vasoactive
drugs were already infused continuously )