Effect of Probiotics Supplementation on the Side Effects of Radiation Therapy Among Colorectal Cancer Patients
Status:
Recruiting
Trial end date:
2022-12-30
Target enrollment:
Participant gender:
Summary
Colorectal cancer (CRC) is one of the most common types of cancer worldwide in general and in
Jordan in specific. The studies that investigate the role of Probiotics supplementation in
improving the inflammatory response, gastrointestinal toxicity and life quality of patients
with colorectal cancer during radiotherapy are limited. So, this study aimed to study the
effect of probiotics on the response of inflammatory markers, gastrointestinal toxicity, and
quality of life in patients with colorectal cancer during radiation therapy.
An interventional double-blind randomized clinical trial (RCT) design will be used in this
study. Forty patients will be recruited and assigned either to receive 3 times a day
probiotic supplement or to be control with no intervention. The demographic data,
anthropometric measurements, Cancer Quality of Life Questionnaire and blood samples will be
collected at baseline and at end of radiation therapy. Interleukin-6,
interleukin-1,interleukin-10 IL-10, C-reactive protein, tumor necrosis factor-alpha and
complete blood count (CBC) will be measured.
The results will approve or disapprove the beneficial effect of using probiotics as adjuvant
therapy for CRC patients and other types of cancer to reduce the side effects of radiotherapy
and raise body weight as well as improving their quality of life.