Effect of Probiotic Supplementation on Endothelial Function
Status:
Completed
Trial end date:
2015-03-01
Target enrollment:
Participant gender:
Summary
The study is being performed to determine whether probiotics (GoodBelly) improves blood
vessel function.Probiotics similar to yogurt are living micro-organisms (beneficial to its
host) the lives in the intestine. Patients who have coronary artery disease will be enrolled
in this study. The research results will be used to determine if the type of bacteria present
in the intestines play a role in the pathogenesis of cardiovascular disease. Patients with
coronary artery disease will be enrolled for up to 12 weeks. Patients will take the probiotic
for 6 weeks. Following the 6 week period there is a washout period of 4 weeks, and an
optional antibiotic study called vancomycin. Patients will take the vancomycin for 10 days.
Blood vessel function will be measured by ultrasound before and after the probiotic
supplement and vancomycin antibiotic. Blood will also be taken before and after to evaluate
for markers of inflammation.