Effect of Probenecid on Pexidartinib Pharmacokinetics
Status:
Completed
Trial end date:
2017-03-30
Target enrollment:
Participant gender:
Summary
The primary objective of this trial is to assess the effect of probenecid on the
pharmacokinetics (PK) of single-dose pexidartinib in healthy subjects.
Secondary objectives are to assess the safety and tolerability of pexidartinib alone and in
combination with probenecid.
Participants will be confined to the clinic for approximately 32 days. Blood samples will be
collected for PK analysis of pexidartinib and metabolites at predose and up to 312 hours (h)
post dose.