Effect of Preoperative Intravenous Dexamethasone on Postoperative Pain After Primary Total Hip Arthroplasty

• Status: Unknown status
• Trial end date: 2020-12-31
• Target enrollment: 0
• Participant gender: All

Summary

To compare the effects of preoperative intravenous Dexamethasone between 10 mg and 40 mg with placebo on Postoperative Pain After Primary Total Hip Arthroplasty

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Chiang Mai University
• Treatments: BB 1101; Dexamethasone; Dexamethasone acetate; Pharmaceutical Solutions

Criteria

Inclusion Criteria:

• Age > 18 years

• Undergoing Elective, Primary, unilateral Total Hip arthroplasty

• American Society of Anesthesiology (ASA) physical class 1-3

• BMI < 40 kg/m2

Exclusion Criteria:

• History of previous musculoskeletal injury on the same hip

• History of prior surgery on the same unilateral hip

• History of adverse effects from medication utilized in this study

• Contraindication to spinal anesthesia

• History of psychiatric disorders or cognitive impairment

• Contraindication to Corticosteroid

• Poorly controlled Diabetes mellitus

• History of ischemic heart disease or peripheral arterial disease or cerebrovascular disease

• Hepatic insufficiency (Child-Pugh score > 5)

• Renal insufficiency (Creatinine clearance < 30 mL/min)

• History of cataract or glaucoma or ocular hypertension