Effect of Premedication With Pronase on Mucosal Cleanliness During EGD
Status:
RECRUITING
Trial end date:
2025-09-01
Target enrollment:
Participant gender:
Summary
Gastric cancer and esophageal cancer are common malignant tumors that threaten people's life and health. Esophagogastroduodenoscopy (EGD) is an important tool for screening upper gastrointestinal tumors, especially early tumors, and an effective method for detecting other upper gastrointestinal lesions, including ulcers and polyps. However, during EGD examination, mucus and foam can reduce the cleanliness of the mucosa and limit the operator's visual field, resulting in missed lesions and misdiagnosis. Previous studies have shown that preoperative medication with pronase and dimeticone is correlated with the improvement of upper gastrointestinal mucosal cleanliness. However, the number of samples in such studies is limited, and the artificial judgment is not objective enough to evaluate the cleanliness of upper digestive tract mucosa. And, whether a postural exercise is necessary for premedication with pronase or dimeticone remains unclear. Our team design this experiment to examine the efficacy of using premedication of dimeticone/pronase with a postural exercise on visualization of the mucosa before painless EGD. The investigators aim to provide new evidence to optimize the use of premedication with EGD.
Phase:
NA
Details
Lead Sponsor:
Changhai Hospital
Collaborators:
Affiliated Hospital of Hebei University Anqing Municipal Hospital Beijing Chao-Yang Hospital, Captial Medical University Beijing Friendship Hospital, Captial Medical University Beijing Tiantan Hospital First Affiliated Hospital of Harbin Medical University First Affiliated Hospital of Kunming Medical University Fujian Provincial Hospital General Hospital of Ningxia Medical University Hengshui People's Hospital Huadu District People's Hospital of Guangzhou Huashan Hospital Jining Medical University Jiujiang No.1 People's Hospital Kunshan Hospital of Traditional Chinese Medicine Liaocheng People's Hospital Longgang District People's Hospital of Shenzhen Loudi Central Hospital Nanjing Gaochun People's Hospital Ningbo Medical Center Lihuili Hospital Peking Union Medical College Hospital Qilu Hospital of Shandong University Red Cross Hospital, Hangzhou, China Second Affiliated Hospital of Xi'an Jiaotong University Subei People's Hospital of Jiangsu Province Taihe Hospital Taizhou First People's Hospital The Affiliated Hospital of Inner Mongolia Medical University The Affiliated Hospital Of Southwest Medical University THE FIRST AFFILIATED HOSPITAL OF SHIHEZI UNIVERSITY The First People's Hospital of Lin'an District, Hangzhou The First People's Hospital of TianMen in Hubei Province The People's Hospital of JiangMen The Second Affiliated Hospital of Chongqing Medical University The Second Affiliated Hospital of Harbin Medical University The Second Affiliated Hospital of Kunming Medical University The Second Affiliated Hospital of Shandong First Medical University Xinghua City People's Hospital Yuebei People's Hospital Yunnan Cancer Hospital Zhejiang Provincial People's Hospital Zhoushan Hospital, Zhejiang ZhuZhou Central Hospital