Effect of Pregabalin on Immediate Post-operative and Longterm Pain

• Status: Completed
• Trial end date: 2020-10-01
• Target enrollment: 0
• Participant gender: All

Summary

This study aims to evaluate the incidence of longterm pain after spinal fusion surgery in children and adolescents. In the second part of the study a randomized double-blind clinical trial will be conducted. We compare the effect of pregabalin versus placebo on postoperative pain and oxycodone consumption. We will also be able to evaluate the effect of pregabalin on neurophysiological monitoring during surgery.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Turku University Hospital
• Treatments: Oxycodone; Pregabalin

Criteria

Inclusion Criteria:

1. Adolescent (10-21 years) undergoing spinal fusion for idiopathic scoliosis, spondylolisthesis or Scheuermann kyphosis.

2. Posterior spinal fusion

3. No contraindication for Pregabalin use

4. ASA I-III

5. Written informed consent

Exclusion Criteria:

1. Other spinal pathology or other associated medical condition

2. Major neurologic developmental delay

3. Need for anterior surgery or for vertebral column resection.

4. Preoperative opioid use

5. Inability to use PCA