Effect of Prebiotics on the Gut Microbiome Profile and Beta Cell Function
Status:
Recruiting
Trial end date:
2023-01-01
Target enrollment:
Participant gender:
Summary
Data suggest that intestinal microbiota might be critically involved both in autoimmunity and
in glucose homeostasis. An acetylated and butyrylated form of high amylose maize starch
(HAMS-AB) that increases beneficial short chain fatty acid (SCFA) production has been safe
and effective in disease prevention in mouse type 1 diabetes (T1D) models. The objective of
this application is to assess the effect of administering a prebiotic, such as HAMS- AB, on
the gut microbiome profile, glycemia and β-cell function in humans with T1D.