Effect of Postsurgical Systemic Doxycycline After Regenerative Periodontal Therapy
Status:
Terminated
Trial end date:
2011-02-01
Target enrollment:
Participant gender:
Summary
Study Hypothesis: The administration of 200 mg doxycycline once a day for 7 days after
regenerative periodontal therapy of infrabony defects improves the results of therapy
(clinical vertical attachment gains [CAL-V], bony fill) and reduces postoperative flap
dehiscence and defect exposure.
In each of 90 patients one infrabony defect shall be treated by regenerative techniques
(guided tissue regeneration [GTR], enamel matrix derivative [EMD]). Prior to , 6, 12, and 24
months after surgery clinical measurements (Plaque Index [PlI], probing depth [PD], vertical
clinical attachment level [CAL-V], Gingival Index [GI]) and standardized radiographs are
obtained.
Phase:
Phase 4
Details
Lead Sponsor:
Peter Eickholz
Collaborators:
Dr. August Wolff GmbH & Co. KG Arzneimittel Gaba International AG Heidelberg University