Effect of Postoperative Ketorolac on Bone Healing After Joint Fusion
Status:
Enrolling by invitation
Trial end date:
2021-12-31
Target enrollment:
Participant gender:
Summary
In the midst of the opioid crisis, the use of non-narcotic pain medication has garnered
increased interest, particularly in the field of orthopaedic surgery, where narcotic
medications are routinely prescribed postoperatively. Nonsteroidal anti-inflammatory drugs
(NSAIDs) have the potential to serve as an adjunct analgesic, but many orthopaedic surgeons
have viewed NSAIDs with hesitancy because of evidence that they can lead to delayed bone
healing.
When evaluating bone healing across different NSAID formulas, ketorolac was found to cause no
delay and lead to better union rates when compared to controls and other NSAIDs,
respectively. Previous studies in the orthopaedic spine and trauma literature have suggested
a detrimental effect of NSAIDs, specifically ketorolac, with regards to bone healing, while
others have reported no delay in healing. A recent study from our institution found no
detrimental effects on the healing of ankle fractures with the use of ketorolac in the
immediate postoperative period. Additionally, the use of ketorolac was associated with less
reliance on narcotic pain medications.
The purpose of this prospective randomized study is to evaluate the use of ketorolac on
postoperative pain, opioid requirements, patient satisfaction, complication/reoperation
rates, and delayed and/or nonunion rates in patients undergoing fusion of their first
metatarsophalangeal joint (1st MTPJ) for treatment of end-stage arthritis.
Phase:
Phase 3
Details
Lead Sponsor:
Rothman Institute Orthopaedics
Treatments:
Acetaminophen Acetaminophen, hydrocodone drug combination Aspirin Ketorolac Ketorolac Tromethamine Oxycodone