Effect of Postoperative Additive Systemic Steroids in CRSwNP
Status:
Completed
Trial end date:
2021-02-01
Target enrollment:
Participant gender:
Summary
This study investigate the additive effect of systemic postoperative steroids in patients
with chronic rhinosinusitis (CRSwNP). All patients receive a functional endoscopic sinus
surgery (FESS) followed by topical steroid spray for 3 months. Postoperatively, patients will
be randomized to either an additional systemic steroid or a placebo for 1 month. Patients
will be followed for 2 years. Effect on Nasal Polyp score (NPS), Lund-Kennedy-Score (LKS),
recurrence rates, smell scores, Rhinosinusitis Disability Index (RSDI), Short-Form 36 (SF-36)
and mucus/serum biomarkers will be measured.