Effect of Post-operative Ibuprofen After Surgery for Chronic Rhinosinusitis
Status:
Unknown status
Trial end date:
2018-09-30
Target enrollment:
Participant gender:
Summary
Endoscopic sinus surgery (ESS) for chronic rhinosinusitis (CRS) is a common procedure in the
US, with about 250,000 cases performed annually. Currently, there is no consensus,
evidence-based post-operative pain regimen; with the majority of practitioners opting for a
combination of acetaminophen and narcotics for pain control. Most rhinologists avoid NSAIDs
due to decreased platelet aggregation and the theoretical risk of increased post-operative
bleeding. No studies to date have evaluated the use of ibuprofen in CRS patients following
ESS. Additionally, there is a lack of information regarding the average narcotic requirement
following ESS.
The purpose of this pilot prospective cohort study is to evaluate the use of narcotics in
sinus surgery and the effect of ibuprofen in the non-packed nose following ESS. This
investigation will help to gain understanding of current opioid use in post-op sinus patients
and assess the safety and effectiveness of post-operative ibuprofen administration on pain.
The investigators aim to quantify the average narcotic use following ESS, as well as evaluate
the effect of the addition of ibuprofen to the standard analgesic regimen on pain scores and
post-operative epistaxis. The investigators hypothesize that the use of ibuprofen will
decrease pain scores on a 10-cm visual analogue scale when compared with individuals who do
not use ibuprofen post-operatively, this will lead to decreased opioid use in the
post-operative period. Additionally, the investigators hypothesize no increase in
post-operative bleeding rates, again based on a 10-cm visual analogue scale and bleeding
events.
In summary, this will be the first study to the investigators knowledge to examine the effect
of post-operative ibuprofen use and its effects on opioid use, as well as pain and epistaxis
outcomes, in ESS. By performing this pilot prospective cohort study, the investigators will
be equipped to design and perform the optimal prospective, randomized study evaluating the
effect of NSAID in ESS during the post-operative period. The overarching goal of this
investigation is to decrease opioid use in post-operative pain control following ESS.