Effect of Perioperative Sivelstat Administration for Liver Resection
Status:
Completed
Trial end date:
2008-07-01
Target enrollment:
Participant gender:
Summary
It is reported that sivelstat improved and preserved the postoperative renal function in the
orthopedic management. Moreover because sivelstat reduced the migration of neutrophil, it
improved acute lung injury. During liver resection, Pringle maneuver, clamping the
hepatoduodenal ligament, was performed. Pringle maneuver causes reperfusion injury of the
liver. We have a hypothesis that sivelstat prevent the warm shock of reperfusion injury of
the liver by Pringle maneuver.