Effect of Perimenstrual Ovarian Steroid Supplementation on Perimenstrual Suicidality
Status:
Completed
Trial end date:
2017-11-01
Target enrollment:
Participant gender:
Summary
This within-person, crossover, 2-condition, placebo-controlled study compares the impact of
two perimenstrual conditions on severity of suicidal symptoms in females with past-month
suicidality but minimal risk of imminent suicide attempt. The two conditions are (1) natural
perimenstrual withdrawal from estradiol and progesterone (during placebo), (2) perimenstrual
stabilization of estradiol and progesterone using transdermal estradiol and oral micronized
progesterone.