Effect of Pentoxifylline on Tight Junctions (TJs) of Intestinal Mucosa in Patients With Irritable Bowel Syndrome(IBS)

• Status: Unknown status
• Trial end date: 2013-01-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine the therapeutics effectiveness of oral pentoxifylline treatment in patients with IBS.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Hospital Universitario de Canarias
• Treatments: Pentoxifylline

Criteria

Inclusion Criteria:

• Age between 18 and 65 years old

• Most of the patient with IBS will be chose between the patients who go to Digestive System ambulatory external medical office from our Center.

• Be studied and with clinical monitoring al least 6 months before be included.

• Fulfill with Roma III Criteria for IBS (Gastroenterology 2006;130:1377-90) with moderate-severe seriousness according to Modification Francis Scale

Exclusion Criteria:

• 2 weeks before colon biopsia, any patient cann´t take salicylates, NSAID, antibiotics,anticholinergics,opiates or any other medication / product for asintomatic treatment of diarrea.

• 3 months before colon biopsia, any patient cann´t take medicaments as corticoides, antihistamines or immunosuppressive

• 6 months before colon biopsia, any patient cann´t recive radiotherapy or chemotherapy.

• Pentoxifilina Alergic Reactions

• Pregnants

• Grave kidney failure

• Grave Hepatic failure

• Menthal or legal disability to sign the consent