Effect of Pentoxifylline on Proteinuria in Korean Type 2 Diabetic Patients

• Status: Completed
• Trial end date: 2013-12-20
• Target enrollment: 0
• Participant gender: All

Summary

This multi-center, randomized controlled study aims to evaluate the effects of pentoxifylline on proteinuria in Korean type 2 diabetic patients.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Ajou University School of Medicine
• Collaborators: Bundang CHA Hospital; Gangnam Severance Hospital; Hallym University Medical Center; Myongji Hospital; Yonsei University
• Treatments: Pentoxifylline

Criteria

Inclusion Criteria:

• type 2 diabetes mellitus

• age >=20 years

• spot urine albumin/creatinine ratio > 30mg/g in two consecutive measurements

• patients on ACE-inhibitor or ARB as an anti-hypertensive drug

• blood pressure <= 150/100 mmHg

• HbA1c <10%

Exclusion Criteria:

• taking insulin pentoxifylline, cilostazol, ketas, viagra in 3 months

• ischemic heart disease, stroke, malignant disease, severe infection in 6 months

• serum creatinine > 2.0mg/dl

• severe liver disease or AST, ALT > 3* ULM

• taking systemic steroid in 1 month

• pregnant or plan to become pregnant during the clinical trial

• lactation