Effect of Palmitoylethanolamide on Reducing Opioid Consumption for Below Knee Fracture Fixation
Status:
Recruiting
Trial end date:
2023-06-01
Target enrollment:
Participant gender:
Summary
Palmitoylethanolamide (PEA), a non-psychoactive cannabis compound derived from peanuts, egg
yolks, and soybeans, is an Endogenous FA Amide produced in the body as a biological response
and a repair mechanism in chronic inflammation and chronic pain. In animal and clinical
trials, PEA has also shown evidence of pain reduction, sleep improvement, and increased joint
mobility and function with minimal side-effects. The study team intends to study whether the
inclusion of PEA in conjunction with standard post-surgical medications can reduce pain and
inflammation while decreasing the number of opioids needed.