Effect of PPARĪ³2 Polymorphism and NSAIDs on Acute Alcohol-induced Changes in Serum Estrogens Among Post-menopausal Women
Status:
Completed
Trial end date:
2015-12-01
Target enrollment:
Participant gender:
Summary
Postmenopausal women, stratified by a peroxisome proliferator-activated receptor gamma-2
(PPARG) polymorphism, were given the following treatments in a random order with a 5w
wash-out period: a 400mg ibuprofen tablet or a placebo tablet; both treatments were followed
after 30min by a single acute dose of 0.4g alcohol per kg bw. Serum estrogen levels were
measured before and at three timepoints after alcohol intake. It is hypothesized that the
acute decrease in estrogen sulphate and other markers of estrogens after alcohol intake is
modulated by ibuprofen and by PPARG genotype.